Johnny Depp

Rango / Lars (voice)

Isla Fisher

Beans (voice)

Ned Beatty

Mayor (voice)

Bill Nighy

Rattlesnake Jake (voice)

Abigail Breslin

Priscilla (voice)

Alfred Molina

Roadkill (voice)

Stephen Root

Doc / Merrimack / Mr. Snuggles (voice)

Harry Dean Stanton

Balthazar (voice)

Timothy Olyphant

Spirit of the West (voice)

Ray Winstone

Bad Bill (voice)

Ian Abercrombie

Ambrose (voice)

Gil Birmingham

Wounded Bird (voice)

Claudia Black

Angelique (voice)

Blake Clark

Buford (voice)

John Cothran

Elgin (voice)

Patrika Darbo

Delilah / Maybelle (voice)

George DelHoyo

Señor Flan - Mariachi Accordion (voice)

Maile Flanagan

Lucky (voice)

Charles Fleischer

Elbows (voice)

Beth Grant

Bonnie (voice)